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pubchem-mcp-server

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pubchem.caseyjhand.com

Search PubChem compounds, properties, safety data, bioactivity, and cross-references.

https://pubchem.caseyjhand.com/mcpNo authMCP 2025-11-25v0.6.1last checked 3 Sep 2026spoke MCP on 3 of 3 checks (30 days)initialize in 424 ms

Will my client connect?

Decided from what the probe found at the endpoint, and from what each client's own documentation says it can complete. Every row carries the day that documentation was read.

✓Claude CodeConnects

The endpoint answers an anonymous handshake, so no credential is needed.

claude mcp add --transport http pubchem-mcp-server https://pubchem.caseyjhand.com/mcp

Claude Code docs · read on 2026-08-30

✓Claude (claude.ai & Desktop)Connects

The endpoint answers an anonymous handshake, so no credential is needed.

Settings → Connectors → Add custom connector, then paste https://pubchem.caseyjhand.com/mcp.

Claude (claude.ai & Desktop) docs · read on 2026-08-30

✓ChatGPTConnects

The endpoint answers an anonymous handshake, so no credential is needed.

Settings → Apps → Advanced settings → Developer mode, then create a connector pointing at https://pubchem.caseyjhand.com/mcp.

ChatGPT docs · read on 2026-08-30

✓CursorConnects

The endpoint answers an anonymous handshake, so no credential is needed.

{
  "mcpServers": {
    "pubchem-mcp-server": {
      "url": "https://pubchem.caseyjhand.com/mcp"
    }
  }
}

Cursor docs · read on 2026-08-30

✓VS Code (Copilot)Connects

The endpoint answers an anonymous handshake, so no credential is needed.

{
  "servers": {
    "pubchem-mcp-server": {
      "type": "http",
      "url": "https://pubchem.caseyjhand.com/mcp"
    }
  }
}

VS Code (Copilot) docs · read on 2026-08-30

How to authenticate

Checked against the endpoint by our probe on 3 Sep 2026. These are the capabilities the server advertises, not a prediction about any particular client.

Scheme	No auth
Protected-resource metadata	✕Not found Without it a client has to guess where the authorization server lives.
Anonymous access	Handshake succeeds; 10 tools listable

Tools

pubchem_get_bioactivitypubchem_get_compound_3d_structurepubchem_get_compound_detailspubchem_get_compound_imagepubchem_get_compound_interactionspubchem_get_compound_safetypubchem_get_compound_xrefspubchem_get_summarypubchem_search_assayspubchem_search_compounds

Contract history

2 Sep 2026v0.6.1first recorded contract

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Status badge

Status for a README, from the last probe — cached an hour, so up to seven hours behind the endpoint. Links back to this page.

[![MCP status](https://mcpi.app/servers/pubchem-mcp-server/badge.svg)](https://mcpi.app/servers/pubchem-mcp-server)