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E

ensembl-mcp-server

connects

ensembl.caseyjhand.com

Look up genes, sequences, variants, homologs, and cross-database xrefs from Ensembl REST.

https://ensembl.caseyjhand.com/mcpNo authMCP 2025-11-25v0.6.0last checked 18 Oct 2026spoke MCP on 100% of 87 checks (30 days)initialize in 657 ms

Will my client connect?

Decided from what the probe found at the endpoint, and from what each client's own documentation says it can complete. Every row carries the day that documentation was read.

✓Claude CodeConnects

The endpoint answers an anonymous handshake, so no credential is needed.

claude mcp add --transport http ensembl-mcp-server https://ensembl.caseyjhand.com/mcp

Claude Code docs · read on 2026-08-30

✓Claude (claude.ai & Desktop)Connects

The endpoint answers an anonymous handshake, so no credential is needed.

Settings → Connectors → Add custom connector, then paste https://ensembl.caseyjhand.com/mcp.

Claude (claude.ai & Desktop) docs · read on 2026-08-30

✓ChatGPTConnects

The endpoint answers an anonymous handshake, so no credential is needed.

Settings → Apps → Advanced settings → Developer mode, then create a connector pointing at https://ensembl.caseyjhand.com/mcp.

ChatGPT docs · read on 2026-08-30

✓CursorConnects

The endpoint answers an anonymous handshake, so no credential is needed.

{
  "mcpServers": {
    "ensembl-mcp-server": {
      "url": "https://ensembl.caseyjhand.com/mcp"
    }
  }
}

Cursor docs · read on 2026-08-30

✓VS Code (Copilot)Connects

The endpoint answers an anonymous handshake, so no credential is needed.

{
  "servers": {
    "ensembl-mcp-server": {
      "type": "http",
      "url": "https://ensembl.caseyjhand.com/mcp"
    }
  }
}

VS Code (Copilot) docs · read on 2026-08-30

How to authenticate

Checked against the endpoint by our probe on 18 Oct 2026. These are the capabilities the server advertises, not a prediction about any particular client.

Scheme	No auth
Protected-resource metadata	✕Not found Without it a client has to guess where the authorization server lives.
Anonymous access	Handshake succeeds; 7 tools listable

Tools

ensembl_get_homologyensembl_get_sequenceensembl_get_xrefsensembl_list_speciesensembl_lookup_geneensembl_predict_variantensembl_query_region

Contract history

14 Oct 2026v0.6.03 compatible6 cosmeticinstructions rewritten

Instructions rewritten: ensembl_get_sequence, ensembl_list_species, ensembl_lookup_gene, ensembl_query_region, ensembl://species. The description an agent follows changed; the callable contract may not have.

8 Oct 2026v0.5.1no contract changes

24 Sep 2026v0.5.06 breakinginstructions rewritten

Breaking: ensembl_get_homology, ensembl_get_sequence, ensembl_get_xrefs, ensembl_lookup_gene, ensembl_predict_variant, ensembl_query_region

Instructions rewritten: ensembl_get_sequence, ensembl_query_region. The description an agent follows changed; the callable contract may not have.

19 Sep 2026v0.4.4no contract changes

2 Sep 2026v0.4.3first recorded contract

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Status badge

Status for a README, from the last probe — cached an hour, so up to seven hours behind the endpoint. Links back to this page.

[![MCP status](https://mcpi.app/servers/ensembl-mcp-server/badge.svg)](https://mcpi.app/servers/ensembl-mcp-server)