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chembl-mcp-server

connects

chembl.caseyjhand.com

Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.

https://chembl.caseyjhand.com/mcpNo authMCP 2025-11-25v0.4.0last checked 18 Oct 2026spoke MCP on 100% of 88 checks (30 days)initialize in 560 ms

Will my client connect?

Decided from what the probe found at the endpoint, and from what each client's own documentation says it can complete. Every row carries the day that documentation was read.

✓Claude CodeConnects

The endpoint answers an anonymous handshake, so no credential is needed.

claude mcp add --transport http chembl-mcp-server https://chembl.caseyjhand.com/mcp

Claude Code docs · read on 2026-08-30

✓Claude (claude.ai & Desktop)Connects

The endpoint answers an anonymous handshake, so no credential is needed.

Settings → Connectors → Add custom connector, then paste https://chembl.caseyjhand.com/mcp.

Claude (claude.ai & Desktop) docs · read on 2026-08-30

✓ChatGPTConnects

The endpoint answers an anonymous handshake, so no credential is needed.

Settings → Apps → Advanced settings → Developer mode, then create a connector pointing at https://chembl.caseyjhand.com/mcp.

ChatGPT docs · read on 2026-08-30

✓CursorConnects

The endpoint answers an anonymous handshake, so no credential is needed.

{
  "mcpServers": {
    "chembl-mcp-server": {
      "url": "https://chembl.caseyjhand.com/mcp"
    }
  }
}

Cursor docs · read on 2026-08-30

✓VS Code (Copilot)Connects

The endpoint answers an anonymous handshake, so no credential is needed.

{
  "servers": {
    "chembl-mcp-server": {
      "type": "http",
      "url": "https://chembl.caseyjhand.com/mcp"
    }
  }
}

VS Code (Copilot) docs · read on 2026-08-30

How to authenticate

Checked against the endpoint by our probe on 18 Oct 2026. These are the capabilities the server advertises, not a prediction about any particular client.

Scheme	No auth
Protected-resource metadata	✕Not found Without it a client has to guess where the authorization server lives.
Anonymous access	Handshake succeeds; 7 tools listable

Tools

chembl_dataframe_describechembl_dataframe_querychembl_get_assaychembl_get_bioactivitieschembl_get_drug_infochembl_search_moleculeschembl_search_targets

Contract history

18 Oct 2026v0.4.01 breaking2 cosmeticinstructions rewritten

Breaking: chembl_get_bioactivities

Instructions rewritten: chembl_dataframe_query, chembl_get_bioactivities. The description an agent follows changed; the callable contract may not have.

11 Oct 2026v0.3.3no contract changes

27 Sep 2026v0.3.25 cosmetic

20 Sep 2026v0.3.03 breaking

Breaking: chembl_dataframe_describe, chembl_dataframe_query, chembl_get_bioactivities

2 Sep 2026v0.2.4first recorded contract

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Status badge

Status for a README, from the last probe — cached an hour, so up to seven hours behind the endpoint. Links back to this page.

[![MCP status](https://mcpi.app/servers/chembl-mcp-server/badge.svg)](https://mcpi.app/servers/chembl-mcp-server)